A few people have sent messages about what sliders we are using/recommending for Madden 12.
Here you go!
NTTV Sliders/Settings
Settings –
10 Minute Quarters
Playcalling – Conventional
Acc Clock – 15 Secs
Cam – Standard
Auto Sprint and Strafe – OFF
Injury – 15
Fatigue – 55
Game Speed – Slow
Speed Thresh – 5
Penalties
Offside – 99
False State – 54
Holding – 52
Facemask – 55
DPI – 99 (Rarely Called)
OPI – 99 (Even more rare than DPI)
KR/PRI – 99
Clipping – 25 *Down this low because many kickoff returns will get called back because your blockers are stupid.
Int Grounding – 99 (CPU Is Never Called for this)
Rough Passer – 55
Rough Kicker – 99
USER/CPU
QBA – 40/30
PBK – 15/75 *You will have between 2.5-4 seconds to get a pass off most of the time. Sometimes less, sometimes more.
CTH – 20/55
BRKTKL – 25/0
RBK – 25/40
FUM – 25/50
Pass Defense
React – 10/10
INT – 25/15
PRSH – 40/30
Rush Defense
React – 18/30 *This is being actively looked at. Stopping the run can be a slippery slope in either direction easy or hard.
BLKS – 18/22
TAK – 25/10
SPECIAL TEAMS
FGP – 50 *With the right wind, you can kick a 65 Yarder with a 99 KPW.
FGA – 50
PPW – 55
PAC – 70 *Makes it a little bit more realistic to get kicks to the corner.
KPW – 50
…and now for the little disclaimer for all the slider/sim nazis out there.
Yes, these sliders have faults and no they aren’t perfect. They are set up for the user to have an enjoyable yet challenging game. It may take a little bit of tweaking for you to find your perfect settings, but we hope these are a good start for you!
NoobTubeTV 
I play franchise. How do you keep these settings without having to re-set them for every game? Thanks
You need to make these your settings in the main menu before you start a franchise. Other than Quarter Length and other Franchise Settings, that should be all you need.
Hope that helps.